Director of Manufacturing

My client is a clinical-stage biopharmaceutical company developing next-generation biologic therapies for oncology and immunology. With a growing pipeline and recent Series D funding, they are entering an exciting phase of scale-up as they prepare for commercial launch. They are investing significantly in their capabilities, capacity, and team to transition from clinical to commercial manufacturing. This is a rare opportunity to join at a pivotal moment and shape the future of operations. The Role They are seeking an experienced Director of Manufacturing to lead the manufacturing facility. Reporting to the VP of Operations, you will have full accountability for site manufacturing performance, including production, quality, engineering, supply chain, and continuous improvement. You will lead a team of professionals across multiple shifts and functions, driving operational excellence, regulatory readiness, and a culture of safety, quality, and innovation. Key Responsibilities:

• Lead and develop the manufacturing organisation, building capability and fostering a high-performing, inclusive culture
• Ensure full GMP compliance and regulatory readiness for MHRA and FDA inspections
• Drive technology transfer, process validation, and scale-up activities for late-stage and commercial products
• Develop and execute the site manufacturing strategy, including capacity planning and capital investment
• Deliver against supply, cost, quality, and safety targets
• Partner cross-functionally with R&D, Quality, Regulatory, and Commercial teams
• Champion continuous improvement and operational excellence initiatives Experience Required:
• Significant experience in pharmaceutical or biopharmaceutical manufacturing leadership
• Proven track record of leading GMP manufacturing operations through regulatory inspections
• Experience with biologics manufacturing (upstream/downstream)
• Demonstrated success in tech transfer, process validation, and scale-up
• Strong people leadership skills with experience managing large, multi-disciplinary teams
• Experience operating in a commercial or late-stage clinical environment
• Degree in a relevant scientific or engineering discipline; advanced degree preferred