Post - Doctoral Research Associate in Cancer Genomics

https://www.jobs.manchester.ac.uk/Job/JobDetail?isPreview=Yes&jobid=46104&advert=external We are seeking a motivated and collaborative individual to join our team as a post-doctoral research associate/fellow with cancer genomics research experience. This role offers an exciting opportunity to analyse genomic data and calculate prostate cancer polygenic risk scores for the GP-TEST-Pro study. This clinical study involves a multidisciplinary team of leading academics from the University of Manchester, Queen Mary University London, University College London, and the Institute for Cancer Research and the postholder will be working within a dynamic and inclusive environment. You will be responsible for:

• Receiving, securely storing and managing genomic data in line with University, NHS and study governance requirements.
• Performing genotype and imputed-data quality control, including sample-level and variant-level checks, ancestry and population-structure assessment, allele harmonisation and preparation of analysis-ready datasets.
• Using appropriate genetic analysis tools, such as PLINK/PLINK2 and imputation server outputs, to clean, process and analyse genomic data.
• Calculating and validating a 451-SNV prostate cancer polygenic risk score, including harmonisation of variants, application of published effect sizes and assessment of score distribution.
• Evaluating additional genomic markers or PRS approaches relevant to clinically significant prostate cancer detection.